Sam Achilefu


Ph.D., 1991, University of Nancy, France
Professor, Department of Radiology, Biomedical Engineering, and Biochemistry & Molecular Biophysics

Dr. Achilefu’s expertise is in molecular optical imaging of tumors and angiogenesis as well as the design and development of new molecular probes and nanomaterials for imaging the expression of aberrant genes, proteins, and other pathophysiologic processes. Specific delivery of imaging agents and drugs to target cell organelles or tissue is another area of interest. In addition, our research program involves the biological evaluation of the new materials to assess ligand trafficking in cells, cytotoxicity, cell proliferation, subcellular distribution, enzyme kinetics, and activation of specific molecular pathways in cells. Small animal molecular imaging of pathologic tissues with state-of-the-art optical imaging systems provides preclinical data before human studies. We are also interested in developing tissue-specific multi-modal imaging molecules that harness the strengths of optical with other imaging methods such as magnetic resonance and radionuclear (positron and single photon emission) imaging systems.| Optical Radiology Laboratory